The Night Set
Estrogen Face Cream plus Fine Line Cream. Two prescriptions, two minutes, every night.
Renews every 3 months at $297 until you cancel. Cancel anytime.
Prescription required. After checkout you'll complete a 5-minute online visit, and a licensed provider reviews it.
The first 12 weeks.
Skin feels softer from the estriol while it adjusts to tretinoin. Some dryness or flaking is normal.
Texture looks smoother, tone brighter, and skin stays more comfortable.
Skin looks fuller and firmer, and fine lines look softer.
Typical experience with consistent use. Individual results vary.
Every active, every percentage.
For skin that turned dry, thin and dull as estrogen dropped. Estriol 0.3% · Vitamin C 5% · HA 0.5%.
The prescription retinoid dermatologists have used for decades on fine lines and texture. Tretinoin 0.05% · Niacinamide · Vitamin C.
Full inactive ingredient list: [TODO from Chemistry Rx formula sheet]. Fragrance-free.
Tested before it ships
Two minutes before bed.
Cleanse, then wait 10 minutes until skin is fully dry.
Fine Line Cream first, a pea-sized amount. Estrogen Face Cream on top, one pump. Or as your provider directs.
SPF 30 or higher.
In their words.
★★★★★ 4.9 out of 5 from 164 verified reviews
"Two minutes at night. I didn't have to learn a ten-step routine to see a difference."
"The estrogen cream keeps the tretinoin from drying me out. Best of both."
"Softer, smoother, and my lines are less obvious. Worth it."
Verified patients. Individual results vary.
Skincare that has to prove what's in it.
| Likeness The Night Set | Store-bought serum | Dermatologist office | |
|---|---|---|---|
| Prescription-only active | Yes | No | Yes |
| Strength printed on the label | Yes, exact % | Often not | Varies |
| Reviewed by a licensed provider | Yes, online | No | Yes, in person |
| Batch-tested, report on the box | Yes | No | Rarely |
| Time to start | 5-minute visit | Today | Weeks for an appointment |
| Price | One flat price | $ | Visit + copay + pharmacy |
From checkout to your door.
- 1
Choose your plan
Refills every 1, 3 or 6 months. Change or cancel anytime.
- 2
5-minute online visit
Right after checkout: your skin, history, medications and a few photos.
- 3
A licensed provider reviews it
They confirm the right treatment and strength for your skin.
- 4
Ships in 2 business days
From Chemistry Rx after approval, in a plain box.
Questions, answered plainly.
Why these two together?
Fine Line Cream (tretinoin) works on turnover and texture. Estrogen Face Cream (estriol) works on the thinning and dryness that come with lower estrogen. They cover different problems, so they're often prescribed together.
Is it cheaper than buying both?
Yes. On the 3-month plan the set is $99/mo, versus $118.98/mo for both separately.
What if I'm only prescribed one?
Your provider decides what's right. If only one is prescribed, we refund the difference automatically.
Can I use it while pregnant?
No. Tretinoin is not for use during pregnancy or while trying to conceive.
What if I'm not prescribed?
You get an automatic refund, in full. No need to ask.
How does my plan work?
Your treatment refills on the schedule you choose, every 1, 3 or 6 months, so you never run out. Change, pause or cancel anytime from your account or by contacting support.
Can I use my HSA or FSA?
Yes. You can pay with your HSA or FSA card at checkout.
Not for use during pregnancy, while trying to conceive, or while breastfeeding. Dryness, peeling, redness and irritation are common in the first weeks. Increases sun sensitivity: use daily sunscreen and avoid tanning. Stop waxing treated areas. Estriol is a hormone. Tell your provider about any history of breast, uterine or other estrogen-sensitive cancer, blood clots, or if you are pregnant or breastfeeding. Mild redness or tingling can occur at first. Keep away from children and pets; wash hands after applying.
Your provider reviews your health history and medications before prescribing. Message your care team with any side effects.