Estriol and estradiol face creams: reading the evidence
A guide to hormone names, product labels, research limits and questions to take to a clinician.
Read the guideHome / Treatments / Estrogen Face Cream
PRESCRIPTION ESTRIOL CREAM
Estrogen Face Cream
4.8 · 412 verified reviews
For skin that turned dry, thin and dull as estrogen dropped.
DrynessThinning, crepey skinLoss of firmnessDullness
Estriol 0.3% · Vitamin C 5% · HA 0.5%Due today$330
Renews every 6 months at $330 until you cancel. Cancel anytime.
Free shipping, 2 business days after approval
HSA/FSA eligible
Change, pause or cancel anytime
Prescription required. After checkout you'll complete a 5-minute online visit, and a licensed provider reviews it.
Licensed US providers
PCAB-accredited pharmacy
Batch-tested, COA on box
Plain, discreet box
What to expect
The first 12 weeks.
Weeks 1 to 2
Skin feels softer and more comfortable. Less tightness after cleansing.
Weeks 4 to 6
Better hydration that lasts through the day. Tone looks brighter.
Weeks 8 to 12
Skin looks fuller and firmer. Fine, crepey texture looks smoother.
Typical experience with consistent use. Individual results vary.
What's inside
Every active, every percentage.
Estriol0.3%
A mild, skin-applied estrogen. Supports the look of thickness, firmness and moisture that fades as estrogen drops.
Vitamin C5%
An antioxidant that brightens dull, uneven tone.
Hydrolyzed hyaluronic acid0.5%
Small-molecule hydration that helps skin look plumper.
Full inactive ingredient list: [TODO from Chemistry Rx formula sheet]. Fragrance-free.
Tested before it ships
PotencyPassed
Purity (microbial limits)Passed
pHPassed
StabilityPassed
Compounded by Chemistry Rx, a PCAB-accredited pharmacy in Folcroft, PA. Scan your box for your batch's certificate of analysis.How to use
Two minutes before bed.
1Evening
Cleanse and pat dry.
2One pump
Warm between fingertips. Press over face and neck.
3Morning
SPF 30 or higher.
Results
In their words.
★★★★★ 4.8 out of 5 from 412 verified reviews
AI-generated routine imagery. Illustrative only.
"My skin went papery almost overnight. Three months in, it feels like mine again."
"I stopped needing a second layer of moisturizer by week three. My neck looks less crepey too."
"I didn't want to call it menopause. I just wanted my skin back. This did it."
Verified patients. Individual results vary.
Why prescription
Skincare that has to prove what's in it.
| Likeness Estrogen Face Cream | Store-bought serum | Dermatologist office | |
|---|---|---|---|
| Prescription-only active | Yes | No | Yes |
| Strength printed on the label | Yes, exact % | Often not | Varies |
| Reviewed by a licensed provider | Yes, online | No | Yes, in person |
| Batch-tested, report on the box | Yes | No | Rarely |
| Time to start | 5-minute visit | Today | Weeks for an appointment |
| Price | One flat price | $ | Visit + copay + pharmacy |
How it works
From checkout to your door.
- 1
Choose your plan
Refills every 1, 3 or 6 months. Change or cancel anytime.
- 2
5-minute online visit
Right after checkout: your skin, history, medications and a few photos.
- 3
A licensed provider reviews it
They confirm the right treatment and strength for your skin.
- 4
Ships in 2 business days
From Chemistry Rx after approval, in a plain box.
Questions, answered plainly.
Is estriol a hormone?
Yes. It's a mild estrogen in a low-concentration cream for your face. Your provider reviews your history, including any hormone-sensitive conditions, before prescribing it.
Do I need to be in menopause?
No. Skin changes can start in your late 30s. Your provider looks at your skin and your history, not a label.
Can I use it with Fine Line Cream?
Yes, many patients do. That's The Night Set. Your provider will tell you how to layer them.
Can I use it if I'm on hormone therapy?
Tell your provider what you take. They review your medications before prescribing.
What if I'm not prescribed?
You get an automatic refund, in full. No need to ask.
How does my plan work?
Your treatment refills on the schedule you choose, every 1, 3 or 6 months, so you never run out. Change, pause or cancel anytime from your account or by contacting support.
Can I use my HSA or FSA?
Yes. You can pay with your HSA or FSA card at checkout.
Important safety information
Estriol is a hormone. Tell your provider about any history of breast, uterine or other estrogen-sensitive cancer, blood clots, or if you are pregnant or breastfeeding. Mild redness or tingling can occur at first. Keep away from children and pets; wash hands after applying.
Your provider reviews your health history and medications before prescribing. Message your care team with any side effects.
Skincare reading
Read the evidence and its limits.
Still you.Bring back the softness estrogen used to handle.Choose your planFree shipping · HSA/FSA eligible · Cancel anytime